Auditory P300 event related potential in the ischemic stroke

Abstract

Stroke is often associated with cognitive decline u'hich ma1- recover-vand rehatrilitation. T'he accepted "gold srandard" fc cognitive abncirn'ralig'after stroke is a hatlery ol neurcpsrchologicalt various domains.T'{europs,rtcholcgica} testing ciependson lhe r-rrt patient and is cften ccmp{ex anel lilne-cunsumilg. so a neurophysiclogicalmetll*c{ suc}r as ttrre*.r'ert related pctentials I interesting. The P300 conrscnent r:f tile auditory el'ent rElsted representinga brain activitv associatedlr'iih vai'iouscognitive setrectivea.ttention.rnemor]'":*r cieeisionmaking" 'fhe airn of this clarifv' the effects of ischemie str*ke r:n the amplit*cie and latencl' of wnve and to correiatcth.eirchanceswith the h4ini Mental StateEramrnati over a one-vearfoilow-*p peri*d. T'hestudy included60 patients*ith a everbrain infarction(meanage 57'1*5'2 years,range45-17l'ears)'\\e the P300 w-aveusing an auditory oddball paradigmin i:aseiine.6 and lf after infarction. Responseswere recordedfrom f,rontai(Fz) vertex (Czt an,l (Pz) midline electrode sites with a biauricular refbrence, according international 10-20 standard. In the stroke patients F300 latenc:' contl decreasedaver the cbservationperiod with a significantdifferenceafter 6 comparedto baseline(p<0.05)andafter 12monthseomparedto baseline( The amplitude F30C) shos,ed no significant changes over time. Statisti significantnegativecoryelationtretweenF300 latenciesand h,'{MSEscores bas'eXine atPzsite(r:-0.339,p<0"01),after3 months(r:-0'59,p<0'01)andafter months(r:-0.35.p<0.01)afterthestroke. Our stuclyemphasiees theimportanc.c P3CI0latene-v- in the detectionand follow-up of cognitive changesafter isc stroke.