Plasma zinc, copper and insulin levels after zinc supplementation in type 2 diabetic patients

Abstract

Zinc is ini.olved in s*veral firnctions in the iruman organism,including reguiatiorr endocrinesecreti,,:nand insulin. Moreover-hiEh zinc intakerelative to copper ;e ma\rinduet cripporelefieiency,In ",tiewof thesef,acts,the airn of this study s to evaluat* the ei'fects of tra'o tliffelent doses of zinc supplementation ofl sma zinc anc{copper concentrations,tnsulin aredglucoselevels, and FtrOMAIR9'00.\lie studied 24 subjectslr'ith type 2 diabetesmellitus and 24 healthy inJividuals.Zinc is gir.enas zinc gl*conateln dosesof 25 mglfuy and 5S rng/elay during 15 rla-vs, r^,'ithrvashoutpeiiod (10 tt12i befweentreatmenls. lood samples rlere drars,n aller an ervernight fasting in bcth gro$ps. bef,ore and after ariministration of zinc gluconate.Compare t* haseline,plasmazinc concentration incleased,while plasrnacopper concentrati{lndecreasedaf,terzine,supplementation in dosesof 50 mglday in diabetic patients (p<0,S5).Tire Cu/Zn plasrnaratic decreasedin diabeticpatientsafter zinc supplemeretationin dosesof 25 rnglday and J0 mg/dayc*mparedrryitirtrasal'i.aluesmarkedbeforeadrninistrationip<0.05). As erpected Cwl7'nplasmaratir: negativeh' *ott*tut.d rn'ithplasmazinc concerltration after zinc supplementation(r:-0.61, p<0,001) in diatretii:spatients"Fasiing s€rum insuiin, glucose and HO&,'IA-IR.%Pwere not significantly dilf'erent after zinc supplementations comparetn baselinein bclthinvestigatedgroups.ln conclusion" ,zinc supplementationin higher doses of 50 mglday during 15 days shorved red*ctian of- plasma copper ler,el and CwlZn plasrnaratio in true 2 diabetic patients,without influenceon insulin andglucoselevels.