dc.description.abstract | INTRODUCTION: Insulin resistance is when cells in human muscles, fat, and liver do not respond well to insulin and cannot easily take up glucose from blood. As a result, pancreas produce more insulin to help glucose enter in cells. During a period, pancreas can produce enough insulin to overcome cells’ weak response to insulin, blood glucose levels will stay in the healthy range. Prediabetes means blood glucose levels are higher than normal but not high enough to be diagnosed as diabetes. Diabetes mellitus (DM), is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period. Diabetes is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced. In the blood glucose control, referred to as glucose homeostasis involved behind Insulin and Glucagon, many other hormones, neurohormones and receptors, minerals etc. Recent study explains and role of opioid as beta-endorphin and endocannabinoids system in glucose homeostasis. According to the Dr Shimotsuura Y. research, Poppy Seed Oil (Oil 54 extra –Planet of Health) put on umbilicus can induce neural modulation and change pain sensitivity probably through reflex stimulation of endogenous opioid and endocannabinoids system. According to the literature surgery of fundic region of stomach in diabetic patients changed levels of hormones and glucose level, specially hunger hormone Ghrelin, which have influence on Insulin secretion. Administration of Betaendorphin in hyperglycemic condition increase level of insulin and cause normoglycemic effect. CB1 receptors are involved in control of production of Ghrelin. METHODS: By using indirect BDORT and Bottle with Poppy Seed Oil (Oil 54 extra) as a referent substance we tested patient with diabetes and with laboratory proven Insulin Resistance and DM. We found out that all of these patients have three BDORT positive zones: 1. Oval zone on the representative zone of stomach fundus below the ribs on the left side, 2. Navel, 3. Acupuncture point Feng Fu (DU 20). After we confirmed existence of these active zones, we tested 70 patients (20-40 years old) by using Oil 54 extra | en_US |