dc.contributor.author | Мијовић, Милица | |
dc.date.accessioned | 2022-09-19T10:56:51Z | |
dc.date.available | 2022-09-19T10:56:51Z | |
dc.date.issued | 2018-09-19 | |
dc.identifier.citation | Индустрија производње олова и цинка, последице по становништво и уређење и заштита екосистема TR37016 | en_US |
dc.identifier.uri | https://platon.pr.ac.rs/handle/123456789/469 | |
dc.description.abstract | The whey, protein complex, which is product of milk, shows useful effects in prevention as well
as in treatment of many diseases. NFkB is a transcription factor that is activated in response to
various stressors and alcohol induced damage in liver is mediated through its elevated
expression. On the other side, there is a literature data that p53, which is a tumor suppressor gen,
plays a central role in the pathogenesis of alcohol and non-alcoholic fatty liver disease. The aim
of this study was assessment of whey effects on NFkB and p53 protein expression in liver at
chronically alcoholised Wistar rats. 28 Wistar male rats were divided into four groups of 6
animals: the control group, the alcohol group (12% ethanol), the whey group (2g/kg per day) and
the group treated with alcohol and whey in co-administration during 42 days. HKkB and p53
proteins were measured by SDS-PAGE ind immunoblotting. The results showed statistically
significant increase of NFkB protein (p<0.05) in a group of animals treated with ethanol and
whey compared tp the group of animals treated with ethanol. There were not changes of p53
protein expression between the gropus of animals. We can suggest that increased level of NFkB
could be I sign of benefitial effects of whey applied in co-administration of ethanol because of its
dual nature, both in apoptosis and regeneration. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | abstract book of meeting of National Physiological Societies | en_US |
dc.title | The Whey effects on p53 and NFkB protein expression in liver of chronically alcoholized wistar rats | en_US |
dc.title.alternative | abstract book of meeting of National Physiological Societies | en_US |
dc.type | konferencijski-prilog | en_US |
dc.description.version | publishedVersion | en_US |
dc.citation.spage | 107 | |
dc.type.mCategory | M34 | en_US |
dc.type.mCategory | openAccess | en_US |
dc.type.mCategory | M34 | en_US |
dc.type.mCategory | openAccess | en_US |