Antimicrobial activity of new mixed azines of coumarins and heteroaryl aldehydes

Abstract

The azine functional group is a part of numerous compounds exhibiting a range of pharmacological activities. As part of our continuous search for new pharmacologically active compounds, we designed, synthesized, and spectrally characterized a series of mixed azines containing coumarin and another heterocyclic moiety. Antimicrobial activity of the synthesized compounds was evaluated by a microdilution assay against five different microorganisms, namely Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus), Gram-negative bacteria (Escherichia coli and Salmonella enteritidis), and one yeast (Candida albicans). It was found that the tested compounds showed higher inhibitory activity against Gram-negative bacteria, with the greatest sensitivity of E. coli to the derivatives with a pyrrole fragment. B. cereus and C. albicans were the most resistant strains to the tested compounds.