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dc.contributor.authorPešić, Marko
dc.contributor.authorBugarinović, Jovana
dc.contributor.authorMinić, Aleksandra
dc.contributor.authorBogdanović, Goran
dc.contributor.authorTodosijević, Anka
dc.contributor.authorStevanović, Dragana
dc.contributor.authorDamljanović, Ivan
dc.date.accessioned2022-09-26T10:18:53Z
dc.date.available2022-09-26T10:18:53Z
dc.date.issued2020-01
dc.identifier.urihttps://platon.pr.ac.rs/handle/123456789/667
dc.description.abstractThe design, synthesis, spectral and electrochemical characterization of a series of novel pyrrolidine derivatives have been described. The synthesis was achieved by 1,3-dipolar cycloaddition of azomethine ylides and ferrocene-substituted chalcones, while detailed characterization of the compounds was performed by IR, NMR and elemental analyses, followed by X-ray diffraction experiment for one representative. The electrochemical properties of obtained ferrocene-containing heterocycles were examined by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). These techniques revealed the quasi-reversible one-electron oxidation process. DNA-binding capacity of all products was studied using CV and DPV, highlighting a derivative with five times better binding affinity than the others. DFT calculations and molecular docking studies were carried out to gain more exhaustive insight into the type of interactions of the distinguished compound and the nucleic acid.en_US
dc.language.isoen_USen_US
dc.publisherThe Electrochemical Societyen_US
dc.rightsАуторство-Некомерцијално-Без прерада 3.0 САД*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.titleSynthesis and Electrochemical Estimation of DNA-Binding Capacity of Novel Ferrocene-Containing Pyrrolidinesen_US
dc.title.alternativeThe Electrochemical Societyen_US
dc.typeclanak-u-casopisuen_US
dc.description.versionpublishedVersionen_US
dc.identifier.doi10.1149/1945- 7111/ab68cc
dc.citation.volume167
dc.subject.keywordsElectrochemistryen_US
dc.subject.keywordsCycloadditionsen_US
dc.subject.keywordsFerrocenesen_US
dc.type.mCategoryM22en_US
dc.type.mCategoryopenAccessen_US
dc.type.mCategoryM22en_US
dc.type.mCategoryopenAccessen_US


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Prikaz osnovnih podataka o dokumentu

Ауторство-Некомерцијално-Без прерада 3.0 САД
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