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dc.contributor.authorMinić, Aleksandra
dc.contributor.authorVan de Walle, Tim
dc.contributor.authorVan Hecke, Kristof
dc.contributor.authorCombrinck, Jill
dc.contributor.authorSmith, Peter J.
dc.contributor.authorChibale, Kelly
dc.contributor.authorD'hooghe, Matthias
dc.date.accessioned2022-09-26T07:16:10Z
dc.date.available2022-09-26T07:16:10Z
dc.date.issued2020-02
dc.identifier.urihttps://platon.pr.ac.rs/handle/123456789/655
dc.description.abstractThe tropical disease malaria is responsible for more than 400,000 deaths annually, especially in Southeast Asia and Africa. Although the number of malaria cases is declining, there still is an urgent need for novel antimalarial agents. The emergence of hybrid antimalarial agents and the precedence set by the antimalarial drug ferroquine (FQ) prompted us to design new ferrocene-containing quinoline structures. Herein, we report the efficient synthesis of three different series of ferrocene-quinoline conjugates and a class of ferrocene-containing heterotricycles in good to high yields. For all twenty novel ferrocenyl derivatives, electrochemical properties were investigated using cyclic voltammetry and antiplasmodium evaluation against a chloroquine-susceptible NF54 strain of the human malaria parasite Plasmodium falciparum was conducted, pointing to three compounds showing submicromolar potency. Subsequently, cytotoxicity assays against a Chinese Hamster Ovarian cell line and evaluation against a chloroquine-resistant strain of Plasmodium falciparum for these three compounds revealed selective and promising antiplasmodium activity.en_US
dc.language.isoen_USen_US
dc.publisherEuropean Journal of Medicinal Chemistryen_US
dc.rightsАуторство-Некомерцијално-Без прерада 3.0 САД*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.titleDesign and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium propertiesen_US
dc.title.alternativeEuropean Journal of Medicinal Chemistryen_US
dc.typeclanak-u-casopisuen_US
dc.description.versionpublishedVersionen_US
dc.identifier.doi10.1016/j.ejmech.2019.111963
dc.citation.volume187
dc.subject.keywordsQuinolinesen_US
dc.subject.keywordsCyclic voltammetryen_US
dc.subject.keywordsAntiplasmodium evaluationen_US
dc.type.mCategoryM21aen_US
dc.type.mCategoryopenAccessen_US
dc.type.mCategoryM21aen_US
dc.type.mCategoryopenAccessen_US


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Ауторство-Некомерцијално-Без прерада 3.0 САД
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