Prikaz osnovnih podataka o dokumentu
Anxiolytic-like Action of Selected 4-(Alkylamino)-3-nitrocoumarin Derivatives in BALB/c Mice
dc.contributor.author | Randjelović, Pavle | |
dc.contributor.author | Radulović, Niko | |
dc.contributor.author | Stojanović, Nikola | |
dc.contributor.author | Dekić, Vidoslav | |
dc.contributor.author | Dekić, Biljana | |
dc.contributor.author | Stojiljković, Nenad | |
dc.contributor.author | Ilić, Sonja | |
dc.date.accessioned | 2023-04-11T07:57:40Z | |
dc.date.available | 2023-04-11T07:57:40Z | |
dc.date.issued | 2020-06-15 | |
dc.identifier.citation | Ministry of Education, Science and Technological Development of Serbia [Project No. 172061, Contract No. 451-03-68/2020-14/200124] | en_US |
dc.identifier.uri | https://platon.pr.ac.rs/handle/123456789/1186 | |
dc.description.abstract | In this work we explored the possible polypharmacological potential of the already established antimicrobials against gastrointestinal pathogens, 4-(alkylamino)-3-nitrocoumarins, as antianxiety agents, using a battery of in vivo experiments. Three chosen coumarin derivatives, differing in the substituent (sec-butylamino, hexadecylamino, or benzylamino) at position 4, at the doses of 25, 50 and 100 mg kg-1, were evaluated in light/dark, open-field, horizontal wire and diazepam-induced sleep models using male BALB/c mice. Depending on the applied dose, all three tested coumarins displayed a noteworthy anxiolytic-like effect. 4-(sec-Butylamino)-3-nitro-2H-chromen-2-one (1), and 4- (hexadecylamino)-3-nitro-2H-chromen-2-one (2) could be recognized as true anxiolytics in the lowest applied dose, based on three tests, without exerting any sedative effects. Thus, the 3-nitrocoumarin core deserves further chemical diversity exploration in the “antianxiety” direction. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Wiley-VHCA AG, Zurich, Switzerland | en_US |
dc.title | Anxiolytic-like Action of Selected 4-(Alkylamino)-3-nitrocoumarin Derivatives in BALB/c Mice | en_US |
dc.title.alternative | Chemistry & Biodiversity | en_US |
dc.type | clanak-u-casopisu | en_US |
dc.description.version | publishedVersion | en_US |
dc.identifier.doi | 10.1002/cbdv.202000206 | |
dc.citation.volume | 17 | |
dc.citation.issue | 6 | |
dc.citation.spage | e2000206 | |
dc.subject.keywords | coumarin derivatives | en_US |
dc.subject.keywords | anxiety | en_US |
dc.subject.keywords | light/dark test | en_US |
dc.subject.keywords | open-field test | en_US |
dc.type.mCategory | M23 | en_US |
dc.type.mCategory | openAccess | en_US |
dc.type.mCategory | M23 | en_US |
dc.type.mCategory | openAccess | en_US |