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dc.contributor.authorRistić, Milenko
dc.contributor.authorDekić, Biljana
dc.contributor.authorRadulović, Niko
dc.contributor.authorAksić, Marija
dc.date.accessioned2023-03-16T12:33:14Z
dc.date.available2023-03-16T12:33:14Z
dc.identifier.citationMinistry of Education, Science and Technological Development of Serbia [Project No. 172061].en_US
dc.identifier.citationMinistry of Education, Science and Technological Development of Serbia [Project No. 45022].en_US
dc.identifier.citationFaculty of Sciences and Mathematics, University of Priština in Kosovska Mitrovica [Project IJ-0205].en_US
dc.identifier.urihttps://platon.pr.ac.rs/handle/123456789/1114
dc.description.abstractIn this research, the synthesis of a new azine derivative with coumarin moiety was performed in three reaction steps, starting from 4-hydroxycoumarin. The first step in synthesis was the acetylation of 4-hydroxycoumarin to yield 3-acetyl-4-hydroxycoumarin and then the obtained 3-acetyl-4-hydroxycoumarin was reacted with hydrazine hydrate and give a corresponding hydrazone. Condensation of the hydrazone with 4-ethoxy-3-methoxybenzaldehyde afforded the target compound 1-[1-(4-hydroxy-2-oxo-2H-chromen-3-yl)-ethylidene]-2-(4-etoxy-3-methoxybenzylidene)-hydrazine in a good yield. The resulting azine derivative is fully spectrally characterized, including complete assignment of 1H- and 13C-NMR spectra, as well as 2D NMR (1H-1H COSY, NOESY, HSQC and HMBC) spectra. The antioxidant activity of corresponding hydrazone and target compound was evaluated by DPPH method where hydrazone derivative displayed a significant and target azine good antioxidant activity, with IC50 (μM) values 11.69 and 216.60, respectively.en_US
dc.language.isoen_USen_US
dc.publisherFaculty of Sciences and Mathematics, University of Priština in Kosovska Mitrovicaen_US
dc.titleSynthesis, complete assignment of 1H- and 13C-NMR spectra and antioxidant activity of new azine derivative bearing coumarin moietyen_US
dc.title.alternativeBulletin of Natural Sciences Researchen_US
dc.typeclanak-u-casopisuen_US
dc.description.versionpublishedVersionen_US
dc.identifier.doi10.5937/bnsr11-31265
dc.citation.volume11
dc.citation.issue1
dc.citation.spage9
dc.citation.epage16
dc.subject.keywordsSynthesisen_US
dc.subject.keywordsAzinesen_US
dc.subject.keywordsCoumarinsen_US
dc.subject.keywordsSpectral analysisen_US
dc.subject.keywords1H- and 13C-NMRen_US
dc.subject.keywordsAntioxidant activityen_US
dc.type.mCategoryM54en_US
dc.type.mCategoryopenAccessen_US
dc.type.mCategoryM54en_US
dc.type.mCategoryopenAccessen_US


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