Antioxidant activity and acute toxicity of new unsymmetrical azines containing coumarin and one more heterocyclic moieties

Abstract

During our previous work, we prepared a series of mixed azines with a coumarin moiety and different benzaldehydes, and tested their acute toxicity and antioxidant activity. Since heterocyclic compounds possess a broad range of biological activities, in the continuation of our work, we designed, synthesized and fully spectrally characterized a series of new mixed azines starting from 3-acetyl-4-hydroxycoumarin and different heteroaromatic aldehydes. The synthesized compounds were evaluated for their antioxidant activities and the acute toxicity in the brine shrimp Artemia salina model. Pyrrole-containing azine showed the higest antioxidant activity, while the lowest activity was noted for the indole derivative. The highest toxicity rate was observed for the thiophene derivate, while the isoquinoline-coumarin mixed azine was shown to be the least toxic.